β-adrenergic-receptor kinase

Names

[ CAS No. ]:
102925-39-3

[ Name ]:
β-adrenergic-receptor kinase

[Synonym ]:
EC 2.7.11.15
ATP:β-adrenergic-receptor phosphotransferase
[β-adrenergic-receptor] kinase
β-adrenergic receptor-specific kinase
β-AR kinase
β-ARK
β-ARK 1
β-ARK 2
β-receptor kinase
GRK2
GRK3
β-adrenergic-receptor kinase (phosphorylating)
β2ARK
βARK1
β-adrenoceptor kinase
β-adrenoceptor kinase 1
β-adrenoceptor kinase 2
ADRBK1
BARK1
adrenergic receptor kinase
STK15

Biological Activity

[Description]:

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase). Reaction: ATP + [β-adrenergic receptor] = ADP + phospho-[β-adrenergic receptor]

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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