Pentifylline

Names

[ Name ]:
Pentifylline

[Synonym ]:
1-hexyl-3,7-dimethylpurine-2,6-dione
EINECS 213-842-0
MFCD00041424

Biological Activity

[Description]:

Pentifylline is a vasodilator. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, decrease the release of free radicals. Pentifylline has the potential for the research of acute ischaemic stroke[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Bath PM, et al. Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. Cochrane Database Syst Rev. 2004;(3):CD000162.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
452.5ºC at 760mmHg

[ Melting Point ]:
80-81°C

[ Molecular Formula ]:
C₁₃H₂₀N₄O₂

[ Molecular Weight ]:
264.32300

[ Flash Point ]:
227.5ºC

[ Exact Mass ]:
264.15900

[ PSA ]:
61.82000

[ LogP ]:
1.01400

[ Vapour Pressure ]:
2.23E-08mmHg at 25°C

[ Index of Refraction ]:
1.602

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8450000

CHEMICAL NAME :: 1H-Purine-2,6-dione, 3,7-dihydro-1-hexyl-3,7-dimethyl-

CAS REGISTRY NUMBER :: 1028-33-7

BEILSTEIN REFERENCE NO. :: 0270632

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H20-N4-O2

MOLECULAR WEIGHT :: 264.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1040 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 24,431,1973

Safety Information

[ Hazard Codes ]:
Xi: Irritant;Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S36/37-S36

[ RTECS ]:
UO8450000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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