2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT

Names

[ Name ]:
2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT

[Synonym ]:
Pentasodium (2R)-2,3-bis(phosphonatooxy)propanoate
Propanoic acid, 2,3-bis(phosphonooxy)-, sodium salt, (2R)- (1:5)
2,3-diphospho-d-glyceric acid pentasodium salt

Biological Activity

[Description]:

2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Kharaghani D, Kohno S, Minamizaki T, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₃Na₅O₁₀P₂

[ Molecular Weight ]:
375.946

[ Exact Mass ]:
375.868988

[ PSA ]:
204.59000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Polyphosphates and pyrophosphates of hexopyranoses as allosteric effectors of human hemoglobin: synthesis, molecular recognition, and effect on oxygen release.

ChemMedChem 6(1) , 153-68, (2011)

Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobi...

Development of a bifunctional filter for prion protein and leukoreduction of red blood cell components.

Transfusion 55(2) , 330-6, (2015)

Leukofiltration of blood components is currently implemented worldwide as a precautionary measure against white blood cell-associated adverse effects and the potential transmission of variant Creutzfe...

Red blood cell in vitro quality and function is maintained after S-303 pathogen inactivation treatment.

Transfusion 54(7) , 1798-807, (2014)

Over the past decade there has been a growth in the development of pathogen reduction technologies to protect the blood supply from emerging pathogens. This development has proven to be difficult for ...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.