BAY 60-2770
Names
[ CAS No. ]:
1027642-43-8
[ Name ]:
BAY 60-2770
Biological Activity
[Description]:
BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM; demonstrates vasodilator activity in the pulmonary and systemic vascular beds that is enhanced by ODQ and NOS inhibition.
[Related Catalog]:
[In Vivo]
BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1]. BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2]. Animal Model: Obese mice[2] Dosage: 1 mg/kg Administration: p.o.; daily from the 10th to the 12th week Result: Ameliorates detrusor dysfunction in obese mice.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C35H33F4NO5
[ Molecular Weight ]:
623.645