PSB 0788
Names
Biological Activity
[Description]:
PSB-0788 (compound 17), xanthine-8-yl-benzenesulfonamide derivative, is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 (compound 17) can be used for the research for chronic inflammatory lung diseases[1].
[Related Catalog]:
[Target]
IC50: 3.64 nM (A2BAdoR); Ki: 0.393 nM (human, A2B); >1000 nM ( A3 human recombinant); 333 nM ( A2A human recombinant); 1730 nM ( A2A rat brain striatal membranes); 2240 nM ( A1 human recombinant); 386 nM ( A1 rat brain cortical membranes))[1].[1]
[In Vitro]
PSB-0788 (compound 17) has high potency at the A2BAdoR with IC50 value of 3.64 nM. PSB-0788 (compound 17) has good profile of affinity and selectivity (Ki: 0.393 nM ( A2B human recombinant); >1000 nM ( A3 human recombinant); 333 nM ( A2A human recombinant); 1730 nM ( A2A rat brain striatal membranes); 2240 nM ( A1 human recombinant); 386 nM ( A1 rat brain cortical membranes))[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C25H27ClN6O4S
[ Molecular Weight ]:
543.03800
[ Exact Mass ]:
542.15000
[ PSA ]:
132.54000
[ LogP ]:
3.60640