A-940894

Names

[ Name ]:
A-940894

[Synonym ]:
2,4-diamino-5,6-disubstituted pyrimidine,9
UNII-8U5620H545

Biological Activity

[Description]:

A-940894 is a potent histamine H4 receptor antagonist, with Ki values of 7.6 nM (rat H4) and 71 nM (human H4). A-940894 exhibits with anti-inflammatory properties[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

Ki: 7.6 nM (rat H4), 71 nM (human H4)[1].

[References]

[1]. M I Strakhova, et al. In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br J Pharmacol. 2009 May;157(1):44-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₁N₅

[ Molecular Weight ]:
295.38200

[ Exact Mass ]:
295.18000

[ PSA ]:
67.80000

[ LogP ]:
1.94800

Related Compounds

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