GSK 626616

Names

[ Name ]:
GSK 626616

[Synonym ]:
GSK-626616
OKY0RM282V
(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-1,3-thiazol-4(5H)-one
4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-

Biological Activity

[Description]:

GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

[Target]

IC50: 0.7 nM (DYRK3)[1]

[References]

[1]. Connie L. Erickson-Miller, et al. GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia. Blood 2007 110:510;

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
574.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₀Cl₂N₄OS

[ Molecular Weight ]:
401.269

[ Flash Point ]:
301.4±32.9 °C

[ Exact Mass ]:
399.995239

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.755

[ Storage condition ]:
2-8°C

Related Compounds

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