Periglaucine A

Names

[ Name ]:
Periglaucine A

[Synonym ]:
4H,6H-3a,6-Methano-4,11b-propano-1H-[1,3]dioxolo[7,8][2]benzoxepino[4,5-b]pyrrol-13-one, 2,3-dihydro-4,14-dimethoxy-3-methyl-, (3aS,4R,6S,11bS,14R)-
periglaucine A
(1S,11S,13S,14R,15R)-14,15-Dimethoxy-20-methyl-5,7,21-trioxa-20-azahexacyclo[11.4.3.1.0.0.0]henicosa-2(10),3,8-trien-16-one

Biological Activity

[Description]:

Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC50: 204 μM)[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[References]

[1]. Yan MH, et al. Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus. J Nat Prod. 2008 May;71(5):760-3.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
509.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₃NO₆

[ Molecular Weight ]:
373.400

[ Flash Point ]:
261.9±30.1 °C

[ Exact Mass ]:
373.152527

[ PSA ]:
66.46000

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.643

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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