Nemadectin

Names

[ Name ]:
Nemadectin

[Synonym ]:
F 28249a
AC-088
(1'R,2R,4S,4'S,5S,6S,8'R,10'E,13'R,14'E,16'E,20'R,21'R,24'S)-4,21',24'-Trihydroxy-5,11',13',22'-tetramethyl-6-[(2E)-4-methyl-2-penten-2-yl]-3,4,5,6-tetrahydro-2'H-spiro[pyran-2,6'-[3,7,19]trioxatetrac ;yclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-2'-one
Antibiotic S-541A
S541 Factor D
LL F-28249a
(6R,23S,25S)-5-O-Demethyl-28-deoxy-25-[(E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-hydroxymilbemycin B

Biological Activity

[Description]:

Nemadectin (CL-287088), an orally active broad-spectrum endectocide, is highly efficacious against natural infections of all the major canine gastrointestinal helminthes. Anthelmintic activity[1].

[Related Catalog]:

Research Areas >> Infection

[In Vivo]

Nemadectin is highly effective at 0.6 mg/kg BW against natural infections of all major species of canine intestinal helminths, when administered as a single oral dose, either as a liquid or a tablet[1].

[References]

[1]. Doscher ME, et al. Efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths. Vet Parasitol. 1989;34(3):255-259.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
789.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₅₂O₈

[ Molecular Weight ]:
612.793

[ Flash Point ]:
243.8±26.4 °C

[ Exact Mass ]:
612.366211

[ PSA ]:
114.68000

[ LogP ]:
7.09

[ Vapour Pressure ]:
0.0±6.2 mmHg at 25°C

[ Index of Refraction ]:
1.579

Precursor & DownStream

Precursor

DownStream

Related Compounds

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