GSK2324

Names

[ CAS No. ]:
1020567-30-9

[ Name ]:
GSK2324

[Synonym ]:
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-quinolinecarboxylic acid

Biological Activity

[Description]:

GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FXR

Research Areas >> Metabolic Disease

[References]

[1]. Jonathan Y Bass, et al. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₂Cl₂N₂O₄

[ Molecular Weight ]:
533.40200

[ Exact Mass ]:
532.09600

[ PSA ]:
85.45000

[ LogP ]:
8.26420

Related Compounds

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