FMK13918

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD)

SCD[1]

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1]. CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1]. CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1]. CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1]. Cell Proliferation Assay[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 48 h Result: Showed antiproliferation activity. Cell Cycle Analysis[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 48 h Result: Decreased the the population of cells in S-phase by 75%. Apoptosis Analysis[1] Cell Line: H460 cells Concentration: 1 µM Incubation Time: 24 h Result: Induced apoposis H460 cells.

[1]. Hess D,et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010; 5(6):e11394.