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CAY10581

Names

[ CAS No. ]:
1018340-07-2

[ Name ]:
CAY10581

[Synonym ]:
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3S,4S)-
(3S,4S)-4-(Benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione

Biological Activity

[Description]:

CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[Target]

IDO:55 nM (IC50)


[In Vitro]

CAY10581 (100 nM; 24 小时) 消除 IFN-γ 在 MSCs 中的生长抑制[1]。 CAY10581 (化合物 36) 在 100 μM 浓度下 24 小时后对 T-REx 细胞活力的影响极小[2]。 Cell Viability Assay[1] Cell Line: Mesenchymal stem cells (MSCs) Concentration: 100 nM Incubation Time: 24 h post-treatment Result: Abrogated the growth inhibition by IFN-gamma (50 ng/ml) in MSCs.

[References]

[1]. Sanjeev Kumar, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18.  

[2]. Siddaraju V Boregowda, et al. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells. EBioMedicine. 2015 Dec 24;4:62-73.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
548.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H21NO4

[ Molecular Weight ]:
363.406

[ Flash Point ]:
285.7±30.1 °C

[ Exact Mass ]:
363.147064

[ PSA ]:
75.63000

[ LogP ]:
4.52

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.649

Related Compounds