PK 44 phosphate

Names

[ Name ]:
PK 44 phosphate

[Synonym ]:
(3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate (1:1)
(3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
1-Butanone, 3-amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-, (3R)-, phosphate (1:1)

Biological Activity

[Description]:

PK44 phosphate is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 value of 15.8 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Research Areas >> Metabolic Disease

[Target]

IC50: 15.8 nM (DPP-IV)[1]

[References]

[1]. Adrian Maddaford, et al. Indazoles for use as dpp-iv inhibitors. WO2008040995A1 (compound 67)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₆F₅N₇O•H₃PO₄

[ Molecular Weight ]:
527.34

[ Exact Mass ]:
527.110535

Related Compounds

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