N-Acetyl-3-acetoxy-5-phenylpyrrole

Names

[ Name ]:
N-Acetyl-3-acetoxy-5-phenylpyrrole

[Synonym ]:
N-ACETYL-3-ACETOXY-5-PHENYLPYRROLE
1-Acetyl-5-phenyl-1H-pyrrol-3-ol Acetate
4-acetoxy-1-acetyl-2-phenyl-pyrrole

Biological Activity

[Description]:

APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin (HY-13753)-induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase

Research Areas >> Metabolic Disease

[References]

[1]. Zhi-Ming Xiu, et al. 1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4482-4487.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₃NO₃

[ Molecular Weight ]:
243.25800

[ Exact Mass ]:
243.09000

[ PSA ]:
48.30000

[ LogP ]:
2.74050

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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