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CMP-Sialic acid sodium salt

Names

[ CAS No. ]:
1007117-62-5

[ Name ]:
CMP-Sialic acid sodium salt

[Synonym ]:
CMP-Sialic Acid (sodium salt)
cytidine-5''-monophospho-N-acetylneuraminic acid sodium salt
CMP-Neu5Ac
CMP-NeuAc
CMP-NANA
Sodium (2R,4S,5R,6R)-5-acetamido-2-{[{[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(hydroxy)phosphoryl]oxy}-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate

Biological Activity

[Description]:

CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

CMP-Sialic acid (CMP-Neu5Ac), the activated form of Neu5Ac, serves as the common activated sugar donor for all the sialyltransferases to transfer a single sialic acid to an acceptor or a growing oligosaccharide chain. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[2].

[References]

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5.

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H30N4NaO16P

[ Molecular Weight ]:
636.433

[ Exact Mass ]:
636.129211

[ PSA ]:
335.55000

Related Compounds