TI17

Names

[ Name ]:
TI17

Biological Activity

[Description]:

TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Others >> Thyroid Hormone Receptor

[Target]

Thyroid hormone receptor interacting protein 13 (Trip13)[1]

[References]

[1]. Chang S et al. TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage. Cancer Med. 2023 Nov 9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂N₂O₃

[ Molecular Weight ]:
374.43

Related Compounds

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