4-BUTYROTHIOLACTONE
Names
[ CAS No. ]:
1003-10-7
[ Name ]:
4-BUTYROTHIOLACTONE
[Synonym ]:
Thiacyclopentan-2-one
EINECS 213-700-8
Thiobutyrolactone
2(3H)-Thiophenone,dihydro
2-Oxothiolane
dihydrothiophen-2(3H)-one
4-Butyrothiolactone
Tetrahydro-2-thiophenone
5-oxotetrahydrothiophene
MFCD00005479
4-Thiobutyrolactone
2-THIOPHENONE,TETRAHYDRO
Chemical & Physical Properties
[ Density]:
1.206g/cm3
[ Boiling Point ]:
197.4ºC at 760mmHg
[ Melting Point ]:
138 °C
[ Molecular Formula ]:
C4H6OS
[ Molecular Weight ]:
102.15500
[ Flash Point ]:
87.6ºC
[ Exact Mass ]:
102.01400
[ PSA ]:
42.37000
[ LogP ]:
1.04000
[ Vapour Pressure ]:
0.38mmHg at 25°C
[ Index of Refraction ]:
n20/D 1.523(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XN1930000
- CHEMICAL NAME :
- 2-Thiophenone, tetrahydro-
- CAS REGISTRY NUMBER :
- 1003-10-7
- BEILSTEIN REFERENCE NO. :
- 0105273
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C4-H6-O-S
- MOLECULAR WEIGHT :
- 102.16
- WISWESSER LINE NOTATION :
- T5SVTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1860 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,249,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 199 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,846,1971
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
22
[ Safety Phrases ]:
S36
[ RIDADR ]:
UN3334 9
[ RTECS ]:
XN1930000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Macromolecules 31(15) , 4746-52, (1998)
Poly(ester-alt-sulfide) (polymer 1) was synthesized by the alternating copolymerization of glycidyl phenyl ether (GPE) with gamma-thiobutyrolactone (TBL) catalyzed by either quaternary onium salts or ...
Metabolic response against sulfur-containing heterocyclic compounds by the lignin-degrading basidiomycete Coriolus versicolor.Appl. Microbiol. Biotechnol. 58(4) , 517-26, (2002)
The fungal conversions of sulfur-containing heterocyclic compounds were investigated using the lignin-degrading basidiomycete Coriolus versicolor. The fungus metabolized a series of sulfur compounds--...
Mechanism of hydrolysis and aminolysis of homocysteine thiolactone.Chemistry 12(15) , 4144-52, (2006)
Homocysteine thiolactone (tHcy) is deemed a risk factor for cardiovascular diseases and strokes, presumably because it acylates the side chain of protein lysine residues ("N-homocysteinylation"), ther...