AMG-076

Names

[ Name ]:
AMG-076

[Synonym ]:
unii-ogb0t3ag23
amg 076

Biological Activity

[Description]:

AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24)

Research Areas >> Metabolic Disease

[References]

[1]. Alykhan S Motani, et al. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₉F₃N₂O₅S

[ Molecular Weight ]:
620.72300

[ Exact Mass ]:
620.25300

[ PSA ]:
119.08000

[ LogP ]:
8.16160

Related Compounds

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