Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils
…, KL Jiménez-Aliaga, P Bermejo-Bescós…
Index: Ortega, Andrea; Rincon, Angela; Jimenez-Aliaga, Karim L.; Bermejo-Bescos, Paloma; Martin-Aragon, Sagrario; Molina, Maria Teresa; Csaky, Aurelio G. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2183 - 2187
Full Text: HTML
Citation Number: 25
Abstract
Abstract BACE1 activity, inhibition of Aβ aggregation, and disaggregation of preformed Aβ fibrils constitute the three major targets in the development of small-molecule lipophilic new drugs for the treatment of Alzheimer's disease (AD). Quinones are widely distributed among natural products and possess relevant and varied biological activities including antitumor and antibiotic, inhibition of HIV-1 reverse transcriptase, antidiabetic, or COX-inhibition, ...
Related Articles:
On/off electrochemical switches based on quinone-bisketals
[Fuentes, Noelia; Cienfuegos, Luis Alvarez De; Parra, Andres; Choquesillo-Lazarte, Duane; Garcia-Ruiz, Juan M.; Marcos, M. Luisa; Bunuel, Elena; Ribagorda, Maria; Carreno, M. Carmen; Cardenas, Diego J.; Cuerva, Juan M. Chemical Communications, 2011 , vol. 47, # 5 p. 1586 - 1588]
The synthesis of polyporic acid and atromentin dimethyl ether
[Shildneck; Adams Journal of the American Chemical Society, 1931 , vol. 53, p. 2373,2376]
On/off electrochemical switches based on quinone-bisketals
[Fuentes, Noelia; Cienfuegos, Luis Alvarez De; Parra, Andres; Choquesillo-Lazarte, Duane; Garcia-Ruiz, Juan M.; Marcos, M. Luisa; Bunuel, Elena; Ribagorda, Maria; Carreno, M. Carmen; Cardenas, Diego J.; Cuerva, Juan M. Chemical Communications, 2011 , vol. 47, # 5 p. 1586 - 1588]
The synthesis of polyporic acid and atromentin dimethyl ether
[Shildneck; Adams Journal of the American Chemical Society, 1931 , vol. 53, p. 2373,2376]
Side-chain sulfonated random and multiblock poly (ether sulfone) s for PEM applications
[Vogel, Claus; Komber, Hartmut; Quetschke, Annett; Butwilowski, Wladimir; Poetschke, Albrecht; Schlenstedt, Kornelia; Meier-Haack, Jochen Reactive and Functional Polymers, 2011 , vol. 71, # 8 p. 828 - 842]