Oxidative Heck arylation for the stereoselective synthesis of tetrasubstituted olefins using nitroxides as oxidants

…, S Kirchberg, R Fröhlich, A Studer

Index: He, Zhiheng; Kirchberg, Sylvia; Froehlich, Roland; Studer, Armido Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3699 - 3702

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Citation Number: 63

Abstract

The Heck arylation belongs to the most important methods for CÀC bond formation and has therefore found widespread application in organic synthesis.[1] Various halides or pseudo halides are readily cross-coupled with olefins under Pd catalysis. In contrast, the oxidative Heck reaction using aryl boronic acids in combination with an external oxidant and a Pd catalyst has been less intensively investigated.[2, 3] Oxidative Heck-type coupling is ...

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THE CONSTITUTION AND THE DISSOCIATION OF THE GRIGNARD REAGENT1

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