Journal of the American Chemical Society

Expression, purification, and characterization of TylM1, an N, N-dimethyltransferase involved in the biosynthesis of mycaminose

H Chen, Z Guo, H Liu

Index: Chen; Guo; Liu Journal of the American Chemical Society, 1998 , vol. 120, # 38 p. 9951 - 9952

Full Text: HTML

Citation Number: 36

Abstract

Tylosin (1), produced by Streptomyces fradiae, is an important drug used to treat veterinary Gram-positive and mycoplasma infections as well as to promote livestock growth. 1 This macrolide antibiotic is composed of a polyketide aglycon (tylactone) and three unusual sugarssmycaminose (2), mycarose (3), and mycinose (4). Extensive genetic and phenotypic complementation studies have led to several classes of blocked mutants, revealing the ...