2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators

…, J Schulz, J Pommier, MA Barthelemy, M Huchet…

Index: Liberatore, Anne-Marie; Schulz, Jocelyne; Pommier, Jacques; Barthelemy, Marie-Anne; Huchet, Marion; Chabrier, Pierre-Etienne; Bigg, Dennis Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 13 p. 3521 - 3523

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Citation Number: 16

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium (Na + ) channel were determined. SAR studies led to highly potent Na + channel blockers. ... A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium ( ...