Tetrahedron Letters

Amidation of esters assisted by Mg (OCH 3) 2 or CaCl 2

MW Bundesmann, SB Coffey, SW Wright

Index: Bundesmann, Mark W.; Coffey, Steven B.; Wright, Stephen W. Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3879 - 3882

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Citation Number: 29

Abstract

Magnesium methoxide (Mg (OCH3) 2) and calcium chloride have been shown to facilitate the direct aminolysis of esters by ammonia to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters were converted to the corresponding carboxamides in good yields. Reactions have been run on a larger scale and without the safety liability inherent in the use of magnesium nitride (Mg3N2). Ammonium chloride and amine hydrochlorides have been ...