The conversion of secondary into tertiary amides using benzotriazole methodology

AR Katritzky, G Yao, X Lan, X Zhao

Index: Katritzky, Alan R.; Yao, Guowei; Lan, Xiangfu; Zhao, Xiaohong Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2086 - 2093

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Citation Number: 36

Abstract

The tertiary amide moiety is an important constituent of many biologically significant compounds,'and tertiary amides have frequently been used as precursors to unsymmetrical tertiary amines having different substituenk2 Tertiary amides have usually been prepared by acylation of a secondary amine or by alkylation of a secondary amide. The alkylation of primary and secondary amides has been well investigated and revie~ ed:~ it has been ...