An efficient chemo-enzymatic approach to the enantioselective synthesis of 2-methyl-1, 3-propamedical derivatives

E Santaniello, P Ferraboschi, P Grisenti

Index: Santaniello, Enzo; Ferraboschi, Patrizia; Grisenti, Paride Tetrahedron Letters, 1990 , vol. 31, # 39 p. 5657 - 5660

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Citation Number: 50

Abstract

Abstract Lipase-catalyzed transesterification of 2-methyl-1, 3-propanediol 1 in chloroform affords enantiomerically pure (S)-(−)-acetate 2, from which the (R)-(+)-silyl ethers 4a-b can be efficiently prepared (> 98% ee). The (S)-TBDPS derivative 4b could be also efficiently and enantioselectively prepared by the same enzymatic procedure, starting from racemic 5b.