Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

P Stabile, A Lamonica, A Ribecai, D Castoldi…

Index: Stabile, Paolo; Lamonica, Alessandro; Ribecai, Arianna; Castoldi, Damiano; Guercio, Giuseppe; Curcuruto, Ornella Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3232 - 3235

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Citation Number: 9

Abstract

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron- donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2- imidazolidinone is unprecedented.