Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo [4, 3-d]-1, 2, 3-triazin-4-one nucleosides

S Manfredini, R Bazzanini, PG Baraldi…

Index: Manfredini, Stefano; Bazzanini, Rita; Baraldi, Pier Giovanni; Guarneri, Mario; Simoni, Daniele; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 917 - 924

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Citation Number: 113

Abstract

Ga-e, g, i and of pyrazolo [4, 3-d]-1, 2, 3-triazin-4-ones 12f-1 mediated by silylation with hexamethyldisilazane, with 1-~-0-acetyl-2, 3, 5-tri-~-benzoyl-~-ribofuranose, gave in good yields the corresponding glycosides 7a-e, g, 8g, i, 13f, h, k, and 14f, but could not be applied to compounds 12g, i, j, I. To overcome this occurrence, a different strategy involving the preparation, diazotization, and in situ cyclization of opportune pyrazole glycosides 9 and ...