Synlett

Mild debenzylation of aryl benzyl ether with BCl3 in the presence of pentamethylbenzene as a non-Lewis-basic cation scavenger

K Okano, K Okuyama, T Fukuyama, H Tokuyama

Index: Okano, Kentaro; Okuyama, Kei-Ichiro; Fukuyama, Tohru; Tokuyama, Hidetoshi Synlett, 2008 , # 13 p. 1977 - 1980

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Citation Number: 19

Abstract

Abstract Scope and limitations of the debenzylation conditions for aryl benzyl ether, which was developed during our synthetic studies on yatakemycin, were investigated. The chemoselective debenzylation proceeds at low temperature with a combination of BCl 3 and pentamethylbenzene as a cation scavenger in the presence of various functional groups.