A procedure for preparation of 2-methylquinoline-4-carboxylic acids

MN Zemtsova, PL Trakhtenberg, MV Galkina

Index: Zemtsova; Trakhtenberg; Galkina Russian Journal of Organic Chemistry, 2003 , vol. 39, # 12 p. 1803 - 1803

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Citation Number: 7

Abstract

2-Methylquinoline-4-carboxylic acids are widely used in organic synthesis for the preparation of various derivatives possessing high biological activity [133]. These compounds are usually obtained by the Pfitzinger reaction, ie, by heating a mixture of 5- substituted isatin with acetone in the presence of alkali. For example, 2-methylquinoline-4- carboxylic acid was synthesized in such a way in 50% yield [335], and 2, 6- ...