Design and synthesis of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3 H)-ones as a new class of H1-antihistaminic agents

V Alagarsamy, P Parthiban

Index: Alagarsamy; Parthiban Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 1 p. 65 - 71

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Abstract

A series of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3 H)-ones were synthesized by the reaction of 2-(3-bromopropyl thio)-3-(2-methyl phenyl) quinazolin-4-(3 H)- one with various amines. The starting material, 2-(3-bromopropyl thio)-3-(2-methyl phenyl) quinazolin-4-(3 H)-one was synthesized from 2-methyl aniline. When tested for their in vivo H1-antihistaminic activity on conscious guinea pigs, all the test compounds protected the ...