Journal of the American Chemical Society

Regioselective synthesis of piperidinones by metal-catalyzed ring expansion-carbonylation reactions. Remarkable cobalt and/or ruthenium carbonyl catalyzed …

MD Wang, H Alper

Index: De Wang; Alper Journal of the American Chemical Society, 1992 , vol. 114, # 18 p. 7018 - 7024

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Citation Number: 26

Abstract

Abstract: Carbonylation of pyrrolidines, catalyzed by cobalt carbonyl, results in the formation of piperidinones. The reaction is regiospecific in most cases, and the yield of product is increased when ruthenium carbonyl is present as a second catalyst. The dual catalytic system [Co,(CO),/Ru,(CO) 12] is useful for the novel rearrangement of heterocyclic nitrogen ketones