The Journal of Organic Chemistry

Activated phosphate triesters. Synthesis and reactivity of N-hydroxysuccinimide and N-mercaptosuccinimide esters

TM Chapman, DG Kleid

Index: Chapman,T.M.; Kleid,D.G. Journal of Organic Chemistry, 1973 , vol. 38, p. 250 - 252

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Citation Number: 2

Abstract

Phosphate esters based upon N-hydroxysuccinimide and iV-mercaptosuccinimide have been prepared. It is shown that the reaction of N-hydroxysuccinirnide with dibenzyl phosphate through the agency of diisopropylcarbodiimide can give a variety of products. Low temperatures in nonpolar solvents give the desired esters exclusively. Higher temperatures and polar solvents give mainly tetrabenzyl pyrophosphate. 0, O-Dibenzyl 0-( ...

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