Intermolecular N??Heterocyclic Carbene Catalyzed Hydroacylation of Arynes

AT Biju, F Glorius

Index: Biju, Akkattu T.; Glorius, Frank Angewandte Chemie - International Edition, 2010 , vol. 49, # 50 p. 9761 - 9764

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Citation Number: 88

Abstract

Arynes are highly reactive intermediates endowed with numerous applications in organic synthesis.[1] The introduction of 2-(trimethylsilyl) aryl triflates as mild aryne precursors led to a rapid growth of this field.[2] Arynes have been utilized extensively in transition-metal- catalyzed reactions [3] and, recently, efforts have been devoted to transition-metal-free reactions, which include the initial addition of nucleophiles to arynes and subsequent ...