An efficient synthesis of chalcones based on the Suzuki reaction

S Eddarir, N Cotelle, Y Bakkour, C Rolando

Index: Eddarir, Said; Cotelle, Nicole; Bakkour, Youssef; Rolando, Christian Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5359 - 5363

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Citation Number: 99

Abstract

Chalcones (1,3-diphenyl-2-propen-1-one) and especially chalcones bearing oxygenated function on the aromatic rings are the precursors of all the flavonoids. 1 They are biologically active molecules found in human diet as they are accumulated in many plants and vegetables. 2 During the biosynthesis, chalcones are cyclized stereospecifically into the corresponding chroman-4-one, also called flavanone, by the enzyme chalcone isomerase (CHI, EC ...