Tetrahedron Letters

Use of the vinyloxycarbonyl group for amino protection in peptide synthesis

RA Olofson, YS Yamamoto, DJ Wancowicz

Index: Olofson; Yamamoto; Wancowicz Tetrahedron Letters, 1977 , vol. No.18, p. 1563 - 1566

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Citation Number: 20

Abstract

In this communication we introduce a promising masking agent--the vinyloxycarbonyl or VOC group--for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l_) in dilute aqueous base using the known