Palladium-catalysed ortho arylation of acetanilides

GZ Zhang, CQ Chen, XH Feng, GS Huang

Index: Zhang, Guo-Zhen; Chen, Cheng-Qun; Feng, Xin-Hua; Huang, Guo-Sheng Journal of Chemical Sciences, 2010 , vol. 122, # 2 p. 149 - 155

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Citation Number: 2

Abstract

Abstract The palladium-catalysed direct arylation of acetanilides by using CH activation methodology has been demonstrated. Several acetanilides were coupled with aryl iodides in the presence of 10 mol% of Pd (OAc) 2, 1· 0 equiv of Cu (OTf) 2, and 0· 6 equiv of Ag 2 O to afford the corresponding products in moderate to excellent yields. The results showed that the amount of Ag 2 O was important for this protocol.