Synthetic communications

Convenient Synthesis of Analogs of Aminomethylene gem??Diphosphonic Acid from Amines Without Catalyst

M Wu, R Chen, Y Huang

Index: Wu, Mingshu; Chen, Ruyu; Huang, You Synthetic Communications, 2004 , vol. 34, # 8 p. 1393 - 1398

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Citation Number: 14

Abstract

Geminal bisphosphonates and the corresponding acids which are characterized by a P–C–P linkage are stable pyrophosphates analogs which are completely resistant to enzymatic hydrolysis. They are widely used in the treatment of a number of diseases characterized by an abnormal calcium metabolism, such as Paget's disease, osteoporosis.11. Rodan , GA and Martin , TJ 2000. Therapeutic approaches to bone diseases. Science, 289: 1508–1514. ...