Journal of the American Chemical Society

Potential Purine Antagonists. XX. The Preparation and Reactions of Some Methylthiopurines1

CW Noell, RK Robins

Index: Noell; Robins Journal of the American Chemical Society, 1959 , vol. 81, p. 5997,5999,6006

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Citation Number: 59

Abstract

A study has been made of the reaction of chlorine and various methylthiopurines in absolute and aqueous methanol. In aqueous methanol the alkyl sulfone was isolated. In absolute methanol, replacement of the methylthio group by chlorine was observed in positions 6 and 8 of the purine nucleus. Under these conditions the methylthio group in position 2 was converted to the expected methyl sulfone. A preliminary study of the nucleophilic ...