Aminoketones. I. The Preparation of α-Aminoketones from Di-t-butyl Acetamidomalonate2

AW Schrecker, MM Trail

Index: Schrecker; Trail Journal of the American Chemical Society, 1958 , vol. 80, p. 6077,6078

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Citation Number: 6

Abstract

As part of a program dealing with the preparation of amino acid antimetabolites to be tested for potential effect against experimental tumors, the synthesis of certain a-aminoketone derivatives of the general structure RCOCHzNHR'appeared of interest. Some compounds of this type, such as 6-aminolevulinic acidj3 have been shown to be involved in biochemical pathways, while others have been employed in the synthesis of antibiotic^.^ In a search ...