Heteroatom Chemistry

Substituted pyridopyrimidinones, 1: Convenient PTC alkylation and halogenation of 2??hydroxy??4H??pyrido [1, 2??a] pyrimidin??4??one

M Abass, AS Mayas

Index: Abass, Mohamed; Mayas, Aisha S. Heteroatom Chemistry, 2007 , vol. 18, # 1 p. 19 - 27

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Citation Number: 8

Abstract

Abstract Alkylation of 2-hydroxy-4H-pyrido [1, 2-a] pyrimidin-4-one (1) was investigated under solid–liquid phase transfer catalysis conditions (PTC), using tetrabutylammonium bromide and potassium carbonate. The reaction with alkyl halides led to the formation of various 2-alkoxy products, in fair yields. Reaction of compound 1 with epichlorohydrin and chloroacetonitrile, under the same PTC conditions, afforded novel O1, O3-disubstituted ...