Efficient Suzuki-Miyaura Coupling of Deactivated Aryl Chlorides Catalyzed by an Oxime Palladacycle

DA Alonso, JF Civicos, C Najera

Index: Alonso, Diego A.; Civicos; Najera, Carmen Synlett, 2009 , # 18 p. 3011 - 3015

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Abstract

Abstract Aryl chlorides are efficiently cross-coupled with aryl boronic acids using 0.25 mol% of 4, 4′-dichlorobenzophenone oxime derived palladacycle as precatalyst in the presence of 1 mol% of [HP (t-Bu) 3] BF 4 as ligand, K 2 CO 3 as base, TBAOH as additive, and DMF as solvent under conventional thermal or MW irradiation conditions. Under these simple reaction conditions a wide array of deactivated and hindered aryl chlorides react cleanly ...