Nucleosides, Nucleotides & Nucleic Acids 2003-01-01

Pyrrolidino-DNA.

Adrian Häberli, Alain Mayer, Christian J Leumann

Index: Nucleosides Nucleotides Nucleic Acids 22(5-8) , 1187-9, (2003)

Full Text: HTML

Abstract

We synthesized pyrrolidino-C-nucleosides, incorporated them into oligodeoxynucleotides and investigated their pairing properties. The thermal duplex and triplex stabilities were measured. While triplex formation is destabilized in the case of pyrrolidino-pseudo-U and -T, pyrrolidino-pseudo-iso-C leads to an increase of the Tm value for third strand dissociation. Duplexes are destabilized with all pyrrolidino-C-nucleosides.

Related Compounds

Related Articles:

An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial

2009-01-01

[Reprod. Toxicol. 28(4) , 503-10, (2009)]

Arginine glutamate improves healing of radiation-induced skin ulcers in guinea pigs.

2013-12-01

[Int. J. Radiat. Biol. 89(12) , 1108-15, (2013)]

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

2004-05-03

[Bioorg. Med. Chem. Lett. 14(9) , 2269-74, (2004)]

Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS).

2011-06-01

[Br. J. Pharmacol. 163(4) , 732-44, (2011)]

Tetrakis- and tris(1-Methyluracil) complexes of Pt(II): formation and properties of a carbon-bonded nucleobase species as well as of heternonuclear derivatives.

2007-12-24

[Inorg. Chem. 46(26) , 11356-65, (2007)]

More Articles...