Chemical Communications 2012-06-07

An efficient synthetic approach to 6,5'-(S)- and 6,5'-(R)-cyclouridine.

Christopher S Theile, Larry W McLaughlin

Index: Chem. Commun. (Camb.) 48(45) , 5587-9, (2012)

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Abstract

Here we present new routes for the efficient syntheses of 6,5'-(S)- and 6,5'-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing.

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