Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.
Martijn Verdoes, Ulrik Hillaert, Bogdan I Florea, Myra Sae-Heng, Martijn D P Risseeuw, Dmitri V Filippov, Gijsbert A van der Marel, Herman S Overkleeft
Index: Bioorg. Med. Chem. Lett. 17(22) , 6169-71, (2007)
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Abstract
The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.
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