A one-pot synthesis of 3-arylglutaric anhydrides by reaction of ketene with aromatic aldehydes and ketones

H Matsunaga, K Ikeda, K Iwamoto, Y Suzuki, M Sato

Index: Matsunaga, Hirokazu; Ikeda, Kiyoshi; Iwamoto, Ken-ichi; Suzuki, Yumiko; Sato, Masayuki Tetrahedron Letters, 2009 , vol. 50, # 20 p. 2334 - 2336

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Citation Number: 6

Abstract

Aromatic aldehydes and ketones react with ketene under Lewis acid catalysis to produce β- lactones, which in situ react with another molecule of ketene to produce 3-arylglutaric anhydrides. The mechanism, scope, and limitation of this one-pot synthesis of 3-substituted glutaric anhydrides are discussed.