Some factors affecting the site of alkylation of oxime salts

PAS Smith, JE Robertson

Index: Smith,P.A.S.; Robertson,J.E. Journal of the American Chemical Society, 1962 , vol. 84, p. 1197 - 1204

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Citation Number: 80

Abstract

The product ratio for alkylation of oxime salts on oxygen to that on nitrogen has been studied by chromatographic separation. In the methylation and benzylation of p, p'-disubstituted benzophenone oxime sodium salts in ethanol, electronwithdrawing groups markedly promote alkylation on oxygen. In the alkylation of benzophenone oxime sodium salt with+ substituted benzyl halides, electron-withdrawing substituents also favor alkylation on ...