Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis (trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids

L Grigorjeva, A Jirgensons

Index: Grigorjeva, Liene; Jirgensons, Aigars European Journal of Organic Chemistry, 2011 , # 13 p. 2421 - 2425

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Citation Number: 9

Abstract

Abstract Lewis acid catalyzed cyclization of trichloroacetimidates derived from 1, 4- butenediols and 1, 5-butenediols was achieved to give 4-vinyl oxazolines and 4- vinyloxazines in good to excellent yields. The cyclization products were transformed to protected unsaturated α-and β-amino acids, thus demonstrating the novel approach to access these important classes of compounds.

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