A FACILE SYNTHESIS OF ACYL-PROTECTED FORMALDEHYDE CYANOHYDRINS
…, RC Baran, ME Craig, JT Jackman
Index: Byers, Jeffrey H.; Baran, Robert C.; Craig, Molly E.; Jackman, John T. Organic Preparations and Procedures International, 1991 , vol. 23, # 3 p. 373 - 374
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Citation Number: 5
Abstract
In the course of several ongoing studies, several acyl-protected formaldehyde cyanohydrins were required. The only general literature procedure for the synthesis of compounds of this type involves the reaction of glycolonitrile with a variety of acid chlorides.' The drawbacks of this method are that it requires freshly prepared glycolonitrile, and gives only modest yields (48-74%). We describe herein a simpler method, involving the reaction of carboxylate anions with ...
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