Preclinical evaluation of the anti tumour activity of new epoxyde derivatives.
G Atassi, P Dumont, U Fisher, M Zeidler, M Budnowski
Index: Cancer Treat. Rev. 11 Suppl A , 99-110, (1984)
Full Text: HTML
Abstract
As a follow-up to our initial results on the antineoplastic activity of alpha-1,3,5-triglycidyl-s-triazinetrione (alpha TGT, NSC-296934, Teroxirone), many new epoxyde derivatives were tested against murine tumours, mostly against P388 leukaemia, to determine their antineoplastic role and to characterize their specific effect against tumour cells in vivo, as well as to select an analogue with higher anti-cancer properties and superior pharmacological properties. Triglycidyl urazol (TGU, NSC-332488) showed the highest therapeutic activity and a good level of water-solubility which makes this agent a good candidate for phase-one clinical trials.
Related Compounds
Related Articles:
2015-05-30
[Rapid Commun. Mass Spectrom. 29 , 913-8, (2015)]
1984-09-01
[Cancer Res. 44(9) , 4151-6, (1984)]
Occupational contact dermatitis from triglycidyl isocyanurate in a powder paint factory.
1992-01-01
[Contact Dermatitis 26(1) , 59, (1992)]
Phase I study of two schedules of teroxirone.
1987-05-01
[Cancer Treat. Rep. 71(5) , 489-92, (1987)]
Dermal exposure to dry powder spray paints using PXRF and the method of Dirichlet tesselations.
2004-04-01
[Ann. Occup. Hyg. 48(3) , 257-65, (2004)]