Room temperature palladium-catalyzed 2-arylation of indoles.
Nicholas R Deprez, Dipannita Kalyani, Andrew Krause, Melanie S Sanford
Index: J. Am. Chem. Soc. 128(15) , 4972-3, (2006)
Full Text: HTML
Abstract
This communication describes the rational development of a PdII-catalyzed method for the direct 2-arylation of indoles using [Ar-IIII-Ar]BF4. These reactions proceed under remarkably mild conditions (often at room temperature and in the presence of ambient air and moisture), and these features are believed to be the result of a PdII/IV mechanism operating in these systems. These transformations can be used to prepare functionally diverse 2-arylated indoles and pyrroles, and their potential utility has been expanded by the development of an in situ procedure for generating the iodine(III) arylating reagents.
Related Compounds
Related Articles:
2014-06-01
[Neurogastroenterol. Motil. 26(6) , 810-20, (2014)]
Degradation of substituted indoles by an indole-degrading methanogenic consortium.
1991-09-01
[Appl. Environ. Microbiol. 57(9) , 2622-7, (1991)]
2014-08-11
[Anal. Chim. Acta 839 , 74-82, (2014)]
Photodissociation dynamics of N-methylindole, N-methylpyrrole, and anisole.
2009-04-23
[J. Phys. Chem. A 113(16) , 3881-5, (2009)]
Spectroscopic characterization studies of 1-methyl indole with benzene derivatives.
2010-09-15
[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 77(1) , 179-83, (2010)]